Author:
Langsjoen-P-H. Vadhanavikit-S.
Folkers-K.
Source:
Drugs-Exp-Clin-Res. 1985. 11(8). P 577-9.
Journal
Title: DRUGS UNDER EXPERIMENTAL AND CLINICAL
RESEARCH.
Abstract:
Nineteen patients with chronic myocardial
disease (NYHA Classes III and IV) were given Coenzyme Q10 in a
controlled double- blind cross-over study. All had either low
or borderline levels of CoQ10 in their blood, and showed a
significant change into the normal range with oral CoQ10
replacement. Eighteen patients reported improvement in
activity tolerance with replacement therapy. Combined clinical
observations, stroke volume measured by impedance
cardiography, and ejection fractions calculated from systolic
time intervals, all showed significant improvement in parallel
with CoQ10 administration. This application of the principles
of bioenergetics introduces a promising new dimension to the
study and treatment of the complex problem of myocardial
failure.
